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Frameworks for Understanding Addiction
Addiction is complex, and no single explanation is enough. One way to understand it is as a cycle — moving from intoxication or binge, to withdrawal...
Opioid Use Disorder
An Illness of Threat, Pain, and Isolation Opioid use disorder reflects changes in brain circuits that once helped us feel safe and connected (Volkow...
Clinical Reflections
Short reflections from the clinic — and what they reveal about addiction and recovery.
Wisdom Traditions
Approaches to Care from Wisdom Traditions Stigma remains one of the greatest barriers to recovery.The Pew Research Center (2022) found that many...
Every Life Is Grievable: Ethical Heart of Care
Addiction treatment must bridge neuroscience and humanism.Understanding craving/relapse as brain-based reduces moral blame. Stigma isolates;...
Reawakening Plasticity and Connection
Compounds: psilocybin, ibogaine, ketamine → promote neuroplasticity and network integration (Nielson 2018; Davis 2020). Enhance cognitive...
GLP-1 Receptor Agonists: Metabolism Meets Motivation
Drugs such as semaglutide (Ozempic) and liraglutide (Victoza) decrease nucleus accumbens dopamine release and cue-induced craving (Sorensen et al.,...
Kappa-Opioid Receptor (KOR) Antagonists
Chronic opioid use activates dynorphin–KOR signaling → dysphoria, stress-induced craving (Carlezon & Krystal, 2016). KOR antagonists...
Emerging Treatments for Opioid Use Disorder
Despite all we know — and despite the success of methadone and buprenorphine — opioid use disorder remains one of the most lethal chronic illnesses...
Emerging Frontiers
Emerging Frontiers New treatments in development are looking beyond the opioid receptor alone. They are exploring ways to help the brain recover...
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